regulation of bile acid synthesis in humans: availability of newly sythetized cholesterol is a limiting fator during pharmacological inhibition of bile acid recirculation.

In conditions of chronically stimulated bile acid syntehsis , obtained by pharmacological interruption of bile acid recirculation, inhibition of HMGCoA-reductase induces a relative reduction of Bile Acids synthesis rates. These data suggets taht newly synthesized cholestreol avilabuility maybe a limiting factor for bile acid synthesis under these conditions as previously observed in bile fistula patients.These findings indirectly suggedt a feedforward stimulation exerted by intracellular newly synthesized choletsreol on bile acids synthesis which might involve nuclear receptor and/or coactivators of 7 alpha hydroxylase transcription.