'Progressive Myoclonus Epilepsy' in a Down Syndrome patient with Alzheimer's Disease | ['Epilessia Mioclonica Progressiva' in paziente affetta da Sindrome di Down con Malattia di Alzheimer]

Progressive Myoclonus Epilepsy (PME) has been reported to be an unusual manifestation of early-onset Alzheimer's Disease. We describe the case of a 46-year-old woman with Down Syndrome (47, XX +21), who developed a PME-like epilepsy together with an Alzheimer type deterioration. Our neurophysiological findings seem to confirm the peculiarity of this association also in Down Syndrome.