Evaluation of a possible relationship between medication-overuse headache and potential renal dysfunctions by a proteomic study on urine samples
Abstract
Data di Pubblicazione:
2012
Citazione:
Evaluation of a possible relationship between medication-overuse headache and potential renal dysfunctions by a proteomic study on urine samples / Bellei, E., Monari, E., Bergamini, S., Cuoghi, A., Tomasi, A., Guerzoni, S., A., B., Pini, L.A.. - In: THE JOURNAL OF HEADACHE AND PAIN. - ISSN 1129-2369. - STAMPA. - 13(suppl):(2012), pp. S17-S17. (XXVI National Congress of the Italian Society for the Study of Headaches. Pharmacological therapies and beyond Modena, Italy October 26 – 28, 2012).
Abstract:
This proteomic study confirms the previous finding of alterations
in urinary proteins excreted in MOH patients. Some of these proteins, identified as over-expressed particularly in NSAIDs abusers, were related to different renal dysfunctions and, probably in the development of CA. Proteomic analysis of urine proteins by the combination of 2-DE and MS could improve the knowledge of the pathophysiology of the MOH condition and identify early biomarkers to prevent the potential drug overuse-induced nephrotoxicity
in urinary proteins excreted in MOH patients. Some of these proteins, identified as over-expressed particularly in NSAIDs abusers, were related to different renal dysfunctions and, probably in the development of CA. Proteomic analysis of urine proteins by the combination of 2-DE and MS could improve the knowledge of the pathophysiology of the MOH condition and identify early biomarkers to prevent the potential drug overuse-induced nephrotoxicity
Tipologia CRIS:
Abstract in Rivista
Keywords:
headache; drug abuse; nephrotoxicity; proteomics; urine
Elenco autori:
Bellei, Elisa; Monari, Emanuela; Bergamini, Stefania; Cuoghi, Aurora; Tomasi, Aldo; Guerzoni, Simona; A., Bazzocchi; Pini, Luigi Alberto
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Titolo del libro:
Proceedings
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