Predictive Accuracy of VACS Index for all cause Mortality in HIV-infected People enrolled in a large cohort in Italy

Objective: To determine the Accuracy of VACS index to predict 5-years all-cause mortality and to compare it with thet of other prognostic indices in the ICONA cohort. Conclusion: The VACS index mortality risk demonstrated a very good predictive accuracy in cART-treated HIV infected patients seen for care in Italy, overall and in specific subgroups under-represented in cohorts used to derive and previously validate the index. Overall its predictive value was similar to other more parsimonious indices. Late presentation of HIV and virological response to cART were independent predictors of having a high VACS score.