Skip to Main Content (Press Enter)

×
Home
Corsi
Insegnamenti
Professioni
Persone
Pubblicazioni
Strutture
Terza Missione
Attività
Competenze

UNI-FIND

|

UNI-FIND

unimore.it

×
Home
Corsi
Insegnamenti
Professioni
Persone
Pubblicazioni
Strutture
Terza Missione
Attività
Competenze

Pubblicazioni

JOURNAL OF MEDICINAL CHEMISTRY

Rivista

Codice:

E092714

ISSN:

0022-2623

Dati Generali

Dati Generali

Pubblicazioni (102)

Ordina Pubblicazioni:

ascendente
decrescente

1 '-Benzyl-3,4-dihydrospiro[2H-1-benzothiopyran-2,4 '-piperidine] (Spipethiane), a potent and highly selective sigma(1) ligand

Articolo

1,3-Dioxolane-Based Ligands as a Novel Class of Alpha1-Adrenoceptor Antagonists

Articolo

1-Benzopyran-4-one antioxidants as aldose reductase inhibitors

Articolo

2-(2-phenylcyclopropyl) imidazolines: Reversed enantioselective interaction at I-1 and I-2 imidazoline receptors

Articolo

2-{[(2-(2,6-Dimethoxyphenoxy)ethyl]}-1,4-benzoxathiano:A New Antagonist With High Potency and Selectivity Toward alpha1-Adrenoreceptors.

Articolo

2′-Deoxyuridine 5′-Monophosphate Substrate Displacement in Thymidylate Synthase through 6-Hydroxy-2H-naphtho[1,8-bc]furan-2-one Derivatives

Articolo

A Common Mechanism Underlying Promiscuous Inhibitors from Virtual and High-Throughput Screening

Articolo

Adenosine A(2A) Receptor-Antagonist/Dopamine D(2) Receptor-Agonist Bivalent Ligands as Pharmacological Tools to Detect A(2A)-D(2) Receptor Heteromers

Articolo

Alanine Mutants of the Interface Residues of Human Thymidylate Synthase Decode Key Features of the Binding Mode of Allosteric Anticancer Peptides

Articolo

Alpha2-Adrenoceptors Profile Modulation anf High Antinociceptove Activity of (S)-)2-[1-(Biphenyl-2-yloxy)ethyl]-4,5-dihydro-1H-imidazole

Articolo

Anti-metastatic Inhibitors of Lysyl Oxidase (LOX): Design and Structure-Activity Relationships

Articolo

Antibacterial agent discovery using thymidylate synthase biolibrary screening

Articolo

Antitarget, Anti-SARS-CoV-2 Leads, Drugs, and the Drug Discovery-Genetics Alliance Perspective

Articolo

BRAF inhibitors based on an imidazo[4,5]pyridin-2-one scaffold and a meta substituted middle ring

Articolo

Characterization of 2,4-Diamino-6-oxo-1,6-dihydropyrimidin-5-yl Ureido Based Inhibitors of Trypanosoma brucei FolD and Testing for Antiparasitic Activity

Articolo

Click Chemistry in Lead Optimization of Boronic Acids as β-Lactamase Inhibitors

Articolo

Comprehensive mechanistic analysis of hits from high-throughput and docking screens against β-lactamase

Articolo

Conformational Propensity and Biological Studies of Proline Mutated LR Peptides Inhibiting Human Thymidylate Synthase and Ovarian Cancer Cell Growth

Articolo

Corrections to pyridoimidazolones as novel potent inhibitors of v-raf murine sarcoma viral oncogene homologue B1 (BRAF) (Journal of Medicinal Chemistry (2009) 52, (2255-2256) DOI: 10.1021/jm801509w)

Articolo

Design and exploration of novel boronic acid Inhibitors reveals important Interactions with a clavulanic acid-resistant sulfhydryl- variable (SHV) β‑ lactamase

Articolo

Design, Synthesis, Strucural Studies, Biological Evaluation, and Computational Simulations of Novel Potent AT1 Angiotensin II Receptor Antagonists Based on the 4-Phenylquinoline Structure

Articolo

Design, synthesis, and physicochemical and biological characterization of a new iron chelator of the family of hydroxychromenes

Articolo

Design, synthesis, crystal structures and antimicrobial activity of sulfonamide boronic acids as beta-lactamase inhibitors

Articolo

Designing Chimeric Molecules for Drug Discovery by Leveraging Chemical Biology

Articolo

Development of novel, highly potent inhibitors of V-RAF murine sarcoma viral oncogene homologue B1 (BRAF): Increasing cellular potency through optimization of a distal heteroaromatic group

Articolo

Discovery of Multitarget Antivirals Acting on Both the Dengue Virus NS5-NS3 Interaction and the Host Src/Fyn Kinases

Articolo

Docking and database screening reveal new classes of Plasmodium falciparum dihydrofolate reductase inhibitors

Articolo

Dual Kinase-Bromodomain Inhibitors in Anticancer Drug Discovery: A Structural and Pharmacological Perspective

Articolo

Enantioselectivity of Muscarinic Antagonists. 2,2-Dicyclohexyl-5-((dimethylamino)methyl)-1,3-oxathiolane Methiodide and Related 3-oxide.

Articolo

Enantioselectivity of Muscarinic Antagonists. Isomeric 2-Cyclohexyl-2-phenyl-5-(dimethylamino)methyl)-1,3-oxathiolane

Articolo

Enhancement of Benzothiazoles as Pteridine Reductase-1 Inhibitors for the Treatment of Trypanosomatidic Infections

Articolo

Evaluation of Amides, Carbamates, Sulfonamides, and Ureas of 4-Prop-2-ynylidenecycloalkylamine as Potent, Selective, and Bioavailable Negative Allosteric Modulators of Metabotropic Glutamate Receptor 5

Articolo

Exploring Translocator Protein (TSPO) Medicinal Chemistry: An Approach for Targeting Radionuclides and Boron Atoms to Mitochondria

Articolo

Folic Acid-Peptide Conjugates Combine Selective Cancer Cell Internalization with Thymidylate Synthase Dimer Interface Targeting

Articolo

Further studies on the interaction of the 5-hydroxytryptamine(3) (5-HT3) receptor with arylpiperazine ligands. Development of a new 5-HT3 receptor ligand showing potent acetylcholinesterase inhibitory properties

Articolo

High-Throughput Phenotypic Screening and Machine Learning Methods Enabled the Selection of Broad-Spectrum Low-Toxicity Antitrypanosomatidic Agents

Articolo

Hotspots in an obligate homodimeric anticancer target. structural and functional effects of interfacial mutations in human thymidylate synthase

Articolo

Imidazoline binding sites (IBS) profile modulation: Key role of the bridge in determining I1-IBS or I2-IBS selectivity within a series of 2-phenoxymethylimidazoline analogues

Articolo

Immunostimulation by a partially retro-inverso tuftsin analogue containing Thr 1 (NHCO) (R,S) Lys 2 modification

Articolo

Improving specificity vs bacterial thymidylate synthases through N-dansyl modulation of didansyltyrosine

Articolo

Inhibitor of Ovarian Cancer Cells growth by Virtual Screening: A New Thiazole Derivative Targeting Human Thymidylate Synthase

Articolo

Internalization and stability of a thymidylate synthase peptide inhibitor in ovarian cancer cells

Articolo

Isoxazolo-[3,4-d]-pyridazin-7-(6H)-one as a potential substrate for new aldose reductase inhibitors

Articolo

Mapping and fitting the peripheral benzodiazepine receptor binding site by carboxamide derivatives. Comparison of different approaches to quantitative ligand-receptor interaction modeling

Articolo

Mapping the peripheral benzodiazepine receptor binding site by conformationally restrained derivatives of 1-(2-chlorophenyl)-N-methyl-N-(1-methylpropyl)-3-isoquinolinecarboxamide (PK11195)

Articolo

Mono- and Disubstituted-3,8-diazabicyclo[3.2.1]octane Derivatives as Analgesics Structurally Related to Epibatidine: Synthesis, Activity, and Modeling.

Articolo

Multitarget, Selective Compound Design Yields Potent Inhibitors of a Kinetoplastid Pteridine Reductase 1

Articolo

Negative Allosteric Modulators of A2AR: A New Weapon for Cancer Immunotherapy?

Articolo

New Improved cGMP Analogues to Target Rod Photoreceptor Degeneration

Articolo

Newly synthesized curcumin derivatives: crosstalk between chemico-physical properties and biological activity.

Articolo

Non-peptide ligands for opioid receptors. Design of k-specific agonists

Articolo

Novel Approaches for Targeting Thymidylate Synthase to Overcome the Resistance and Toxicity of Anticancer Drugs

Articolo

Novel Potent BRAF Inhibitors: Toward 1 nM Compounds through Optimization of the Central Phenyl Ring

Articolo

Novel hinge binder improves activity and pharmacokinetic properties of BRAF inhibitors

Articolo

Novel potent AMPA/kainate receptor antagonists: Synthesis and anticonvulsant activity of a series of 2-[(4-alkylsemicarbazono)-(4-amino-phenyl)methyl]-4, 5-methylenedioxyphenylacetic Acid alkyl esters

Articolo

Novel potent and selective central 5-HT3 receptor ligands provided with different intrinsic efficacy. 1. Mapping the central 5-HT3 receptor binding site by arylpiperazine derivatives

Articolo

Novel potent and selective central 5-HT3 receptor ligands provided with different intrinsic efficacy. 2. Molecular basis of the intrinsic efficacy of arylpiperazine derivatives at the central 5-HT3 receptors

Articolo

Optimization of Peptides That Target Human Thymidylate Synthase to Inhibit Ovarian Cancer Cell Growth

Articolo

Optimizing Cell Permeation of an Antibiotic Resistance Inhibitor for Improved Efficacy

Articolo

Phenylpiperazinylalkylamino substituted pyridazinones as potent alpha(1) adrenoceptor antagonists

Articolo

Phthalein derivatives as a new tool for selectivity in thymidylate synthase inhibition

Articolo

Polypharmacology: challenges and opportunities in drug discovery

Articolo

Profiling of Flavonol Derivatives for the Development of Antitrypanosomatidic Drugs

Articolo

Pyridoimidazolones as novel potent inhibitors of v-Raf murine sarcoma viral oncogene homologue B1 (BRAF)

Articolo

Quantitative Structure-Activity Analysis in Dihydropteroate Synthase Inhibition by Sulphones. Comparison with Sulfanilamides.

Articolo

Quantitative Structure-Activity Relationships in Dihydropteroate Synthase Inhibition by Multisubstituted Sulfones. Design and Synthesis of Some New Derivatives with Improved Potency.

Articolo

Resolution, Absolute Configuration and Cholinergic Enantioselectivity of (+) and (-) cis-2-Methyl-5-dimethylaminomethyl-1,3-oxathiolane Methiodide.

Articolo

Resolution, Absolute Configuration and Cholinergic Enantioselectivity of (-) and (+) c-2-Methyl-r-5-((Dimethylamino(methyl)-1,3-oxathiuolane-t-oxide Methiodide and Related Sulfones.

Articolo

Soft docking and multiple receptor conformations in virtual screening.

Articolo

Structure-Activity Relationship in Dihydropteroate Synthase Inhibition by Sulfanilamides. Comparison with the Antibacterial Activity.

Articolo

Structure-Activity Relationships Among Benextramine Related Tetramine Disulfidxe. Chain Length Effect on alpha-adrenoreceptor Blocking Activity.

Articolo

Structure-Activity Relationships Among Benextramine-Related Tetramine Disulfide at Peripheral Alpha-Adrenoreceptors.

Articolo

Structure-Activity Relationships for Prazosin and WB4101 Analogues as alpha1-Adrenoreceptor Antagonist.

Articolo

Structure-Activity Relationships in 1,4-Benzodioxane Related Compounds. Investigation on the Role of the Dehydrodioxane Ring on alpha1-Adrenoreceptor Blocking Activity.

Articolo

Structure-Activity Relationships in Prazosin-Related Compounds. Effect of Replacing a Piuperazine Ring with an Alkanediamine Moiety on alpa1-Adrenoreceptor Blocking Activity.

Articolo

Structure-Based Design of Potent Aromatase Inhibitors by High-Throughput Docking

Articolo

Structure-Based Discovery of Hsp90/HDAC6 Dual Inhibitors Targeting Aggressive Prostate Cancer

Articolo

Structure-Based Selectivity Optimization of Piperidine–Pteridine Derivatives as Potent Leishmania Pteridine Reductase Inhibitors

Articolo

Structure_Activity Relationships among Methoctramine-Related Polymethylene Tetramine. Chain Length and Substituent Effects on M2 Muscarinic Receptor Blocking Activity.

Articolo

Synthesis and anticonvulsant activity of novel and potent 2,3- benzodiazepine AMPA/kainate receptor antagonists

Articolo

Synthesis and anticonvulsant activity of novel and potent 6,7- methylenedioxyphthalazin-1(2H)-ones

Articolo

Synthesis and biological evaluation of new imidazole, pyrimidine, and purine derivatives and analogs as inhibitors of xanthine oxidase

Articolo

Synthesis and evaluation of antiparasitic activities of new 4-[5-(4-phenoxyphenyl)-2H-pyrazol-3-yl]morpholine derivatives

Articolo

Synthesis and structure-activity relationships of 1-aralkyl-4- benzylpiperidine and 1-aralkyl-4-benzylpiperazine derivatives as potent σ ligands

Articolo

Synthesis of 3,4-dihydro-1,2,4-benzothiadiazine 1,1-dioxide derivatives as potential allosteric modulators of AMPA/Kainate receptors

Articolo

Synthesis of a Novel Boronic Acid Transition State Inhibitor, MB076: A Heterocyclic Triazole Effectively Inhibits Acinetobacter-Derived Cephalosporinase Variants with an Expanded-Substrate Spectrum

Articolo

Synthesis, activity, and molecular modeling of a new series of tricyclic pyridazinones as selective aldose reductase inhibitors

Articolo

Synthesis, biological evaluation, and quantitative receptor docking simulations of 2-[(acylamino)ethyl]-1,4-benzodiazepines as novel tifluadom-like ligands with high affinity and selectivity for kappa-opioid receptors

Articolo

Synthesis, biological evaluation, and receptor docking simulations of 2-[(acylamino)ethyl]-1,4-benzodiazepines as kappa-opioid receptor agonists endowed with antinociceptive and antiamnesic activity

Articolo

Synthesis, pharmacological evaluation, and structure-activity relationship and quantitative structure-activity relationship studies on novel derivatives of 2,4-diamino-6,7-dimethoxyquinazoline alpha(1)-adrenoceptor antagonists

Articolo

Synthesis, resolution, and preliminary evaluation of trans-2-amino-6(5)-hydroxy-1-phenyl-2,3-dihydro-1H-indenes and related derivatives as dopamine receptors ligands

Articolo

Synthesis, screening, and molecular modeling of new potent and selective antagonists at the alpha(1d) adrenergic receptor

Articolo

Target Flexibility: An Emerging Consideration in Drug Discovery and Design

Articolo

Targeting Class A and C Serine β-Lactamases with a Broad-Spectrum Boronic Acid Derivative

Articolo

Ten years of medicinal chemistry (2005-2014) in the journal of medicinal chemistry: Country of contributors, topics, and public-private partnerships miniperspective

Articolo

The Hippo Pathway and YAP/TAZ-TEAD Protein-Protein Interaction as Targets for Regenerative Medicine and Cancer Treatment

Articolo

The binding of benzenesulfonamides to carbonic anhydrase enzyme. A molecular mechanics study and quantitative structure-activity relationships

Articolo

Three-dimensional quantitative structure-activity relationship analysis of a set of Plasmodium falciparum dihydrofolate reductase inhibitors using a pharmacophore generation approach

Articolo

Tricyclic pyrazoles. 3. Synthesis, biological evaluation, and molecular modeling of analogues of the cannabinoid antagonist 8-chloro-1-(2′, 4′-dichlorophenyl)-N-piperidin-1-yl-1,4,5,6-tetrahydrobenzo[6,7] cyclohepta[1,2-c]pyrazole-3-carboxamide

Articolo

Tricyclic pyrazoles. 4. Synthesis and biological evaluation of analogues of the robust and selective CB 2 cannabinoid ligand 1-(2′, 4′-dichlorophenyl)-6-methyl-N-piperidin-1-yl-1,4-dihydroindeno[1,2-c] pyrazole-3-carboxamide

Articolo

Virtual Screening and X-ray Crystallography Identify Non-Substrate Analog Inhibitors of Flavin-Dependent Thymidylate Synthase

Articolo

Virtual screening identification of nonfolate compounds, including a CNS drug, as antiparasitic agents inhibiting pteridine reductase

Articolo

No Results Found

«
‹

{pageNumber}

›
»

{startItem} - {endItem} di {itemsNumber}

Utilizzo dei cookie

Realizzato con VIVO | Designed by Cineca | 26.5.2.0