The project will address the issue of designing a portable and reliable device in the UV band to perform a multi-gas detection of some mixtures of interest in the identification of possible causes of lung disorders. It is actually well-known that some exhaled gasses may concur in the definition of dysfunctions and diseases connected to the lungs. Asthma, and bacterial affections, in general, are correlated to the presence in the breath of some specific gasses in very low concentrations, which may range, depending on the involved species, from some hundreds of ppb up to some tens of ppm. In the present proposals, three research units will focus their efforts on designing and characterizing the performance of an instrument, relying on a photoacoustic (PA) chamber, suited for the detection of specific breath gasses. The baseline of this project will be the design of an optimized measurement chamber and the development of the most suited cost-effective electronics properly arranged to provide high reliability and long-term stability in multi-gas sensing. The overall system will be composed of a single or multi-chamber arrangement able to host the exhaled gas and on one or more than one optical sources in the UV bandwidth in accordance with the selected species adsorption spectra to induce time variable gas thermal expansion and therefore a pressure wave so that the system can gather the sound waves generated and detect the gas concentrations depending on the acoustic system response. The selected gasses, out of the literature review will be NO2, methane, and acetone, since such gasses can be connected to several pathologies affecting the lungs. The system will be a low-cost integrated architecture, designed to represent a possible point of care to be deployed to personal small healthcare structures enabling a fast, early stage, and personalized diagnosis of specific lung malfunctions, diseases, and disorders in general. The same system, exploited for continuous monitoring, could also be useful to evaluate drug effectiveness over time in both drug challenges and emergency situations and therapies.