Exploring the role of HSPB3 in chromatin remodeling for neuromuscular junction maintenance: implications for peripheral motor neuropathies
Project The HSPB3 gene encodes the small heat shock protein HSPB3. HSPB3 mutations are associated with distal hereditary motor neuropathy (dHMN2C) and congenital myopathy. This project focuses on the molecular functions of HSPB3 and how its mutations contribute to aging and neuromuscular degeneration.