Evaluation of bioadhesive properties of microspheres using an "ex vivo" test

The purpose of this work was to evaluate the bioadhesive properties of microspheres based on sodium alginate and BSA prepd. by a spray-drying technique. The microspheres were cross-linked using a two steps process with calcium chloride and various amts. of chitosan. The bioadhesiveness of these systems was evaluated using a "ex vivo" method that allowed quant. results to be drawn. It was concluded that the crosslinking step using different amts. of chitosan, even if involved the sites implicated in the bioadhesive process, did not modified the good bioadhesiveness of the calcium alginate microspheres.