Altered mithocondrial RNA production in adipocytes from HIV-infected individuals with lipodystrophy
Abstract
Data di Pubblicazione:
2005
Citazione:
Altered mithocondrial RNA production in adipocytes from HIV-infected individuals with lipodystrophy / Galluzzi, L.; Pinti, Marcello; Guaraldi, Giovanni; Mussini, Cristina; Troiano, L.; Roat, E.; Giovenzana, C.; Nemes, E.; Nasi, M.; Orlando, G.; Salomoni, P.; Cossarizza, Andrea. - In: ANTIVIRAL THERAPY. - ISSN 1359-6535. - STAMPA. - 10 (2):(2005), pp. M91-M99. ( 1st Meeting on Mithocondrial toxicity and HIV Infection: Understanding the pathogenesis for a therapeutic approach Modena -Italy 19-21/05/2005).
Abstract:
Damage to mitochondria (mt) is a major side effect of highly active antiretroviral therapy (HAART) tha includes a nucleoside reverse transcriptase inhibitor (NRTI).Such damage is associated with the onset of lipodystrophy in HAART-treated HIV+ patients. To further investigate mt changes during this syndrome, we analysed the expression of mtRNA in adipocytes from lipodystrophic HIV+ patients taking NRTI-containing HAART and compared it with similar cells from healthy individuals.
Tipologia CRIS:
Abstract in Rivista
Keywords:
HIV; antiretroviral therapy; mithocondrial RNA
Elenco autori:
Galluzzi, L.; Pinti, Marcello; Guaraldi, Giovanni; Mussini, Cristina; Troiano, L.; Roat, E.; Giovenzana, C.; Nemes, E.; Nasi, M.; Orlando, G.; Salomoni, P.; Cossarizza, Andrea
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